Patents Exclusively Licensed to Optigenex Inc.

Patent No. 9,457,009: “Methods and Compositions for Preventing and Treating Auditory Dysfunctions”
This invention is directed towards methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically effective salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
Inventor: Guthrie, O’Neil W.
Assignee: The United States of America As represented by the Department of Veterans Affairs.

 Patent No. 9,889,107: “Methods and Compositions for Preventing and Treating Auditory Dysfunctions”
This invention is a divisional of patent number 9,457,009 and is directed towards methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically effective salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
Inventor: Guthrie, O’Neil W.
Assignee: The United States of America As represented by the Department of Veterans Affairs.


Optigenex Patents

Patent No. 6,964,784 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor and DNA repair processes of warm blooded animals."
This patent covers the pharmaceutical use of an Uncaria extract for DNA repair.

Patent No. 7,579,023 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."
The patent is a division of the application which led to the issuance of U.S. Patent No. 6,964,784. Eight claims have been allowed directed to the method for isolating a bioactive component of the Uncaria extract. The claims are further directed to the isolated bioactive component being a carboxy alkyl ester, a quinic action analog, a quinic acid lactone and/or in a pharmaceutical composition.

Patent No. 7,595,064 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."
The patent is a continuation-in-part of the application which issued as U.S. Patent No. 6,964,784. There are two allowed claims which are directed to a method of preparing and administering quinic acid or quinic acid salt to enhance DNA repair.

Patent No. 7,955,626 "Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester."
The patent is a continuation of the application which issued as U.S. Patent No. 7,579,023. There are 20 claims covering the administration and pharmaceutical use of an isolated purified quinic acid alkyl ester or carboxy alkyl ester for DNA repair or treating disorders associated with the DNA repair process.

Patent No. 7,947,312 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."
The patent is a continuation of the application that issued as U.S. Patent No. 7,595,064. There are ten claims directed to a method of enhancing DNA repair or treating disorders associated therewith by administering quinic acid or quinic acid salt where the quinic acid or salt thereof may form an ammonium salt or chelate thereof.

Patent No. 8,372,448 “Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester.”
The patent is a divisional of the application that issued as U.S. Patent No. 7,955,626. There are 20 claims directed to methods of enhancing anti-tumor response and treating disorders associated with anti-tumor response by administering non-topically a purified, isolated quinic acid alkyl acid or a carboxy alkyl ester.

Patent No. 8,372,449 “Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester.”  
This patent is directed towards the methods of enhancing the response to tumor formation and inhibiting tumor formation by administering a pharmaceutical composition comprising a purified and isolated quinic acid or quinic acid salt.

Patent No. 10,098,922 “Increasing Telomere Length in a Cell” This patent is directed toward administering a pharmaceutically effective amount of an aqueous extract of an Uncaria species for a period of time sufficient to increase the length of telomeres in a cell.