Peer Reviewed Oral Studies, Data and Articles

  1. Introduction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria tomentosa. (Sheng, Pero, Amiri, and Bryngelsson: Anticancer Research 1998) View Study

  2. Enhanced DNA repair, immune function and reduced toxicity of AC-11® (CMED-100®), a novel aqueous extract from Uncaria tomentosa. (Sheng, Bryngelsson and Pero: Journal of Ethnopharmacology 1999) View Study

  3. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. (Shen, Pero, Wagner: Phytomedicine 2000) View Study

  4. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. (Sheng, Homgren, Pero 2001) View Study

  5. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncara tomentosa, C-Med-100®. (Lamm, Sheng and Pero: Phyomedicine 2001) View Study

  6. Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. (Pero, Hoppe, Sheng: Journal of Anti-aging Medicine, 2000) View Study

  7. The Serum Thiol Test: Evidence Supporting the Contention That Serum Thiol Concentrations Are Predictive of DNA Repair Capacity. (In House Study 2005) View Study

  8. AC-11® and NF-KB-inhibition…an additional pathway for why AC-11® improves our natural DNA repair processes. (In house data 2005 and summary 2012) View Study

  9. Identification and Quantification of Components in Extracts of Uncaria tomentosa by HPLC-ES/MS. (Montoro, Carbone, Quiroz, De Simone and Pizza: Phytochem anal. 2004) View Study

  10. Surrogate Indication of DNA Repair in Serum After Long Term Chiropractic Intervention-Retrospective Study. (Campbell, Kent, Bane, Amiri, Pero: Journal Vertebral Subluxation Res. 2005) View Study

  11. C-Med 100®, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. (Akesson, Pero, Ivars: Phytomedicine 2003) View Study

  12. An extract of Uncaria tomentosa inhibiting cell division and NF-kB activity without inducing cell death. (Akesson, Lindgren, Pero, Leanderson, Ivars: International Immunopharmacology 2003) View Study

  13. Quinic acid is a biologically active component of Uncaria tomentosa extract C-Med 100®. (Akesson, Lindgren, Pero, Leanderson, Ivars: International Immunopharmacology 2004) View Study

  14. An active ingredient of Cat’s Claw water extracts Identification and efficacy of quinic acid. (Sheng, Akesson, Holmgren, Bryngelsson, Giampapa, Pero: Ethnopharmacology 2005) View Study

  15. Brunswick Labs, Certificate of Analysis, ORAC Value AC-11 View Study

  16. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. (Pero, Amiri, Sheng, Welther and Rich: Phytomedicine 2005) View Study

  17. Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract. (Pero, Giampapa and Vojdani: Journal of Anti-Aging Medicine 2002) View Study

  18. Antioxidant Metabolism Induced by Quinic Acid. Increased urinary Excretion of Tryptophan and Nicotinamide, (Pero, Lund, Leanderson: Phytotherapy Research 2008) View Study

  19. In Vivo Treatment of Humans with Quinic Acid Enhances DNA Repair and Reduces the Influence of Lifestyle Factors on Risk to Disease. (Pero, Lund: International Journal of Biotechnology and Biochemistry 2009) View Study

  20. Historical Development of Uncaria Preparations and Their Related bioactive Components. (Pero: Nova Sciences Publishers, Chapter 10, 2010) View Study

  21. Dietary Quinic Acid Supplied as a Nutritional Supplement AIO + AC-11 leads to Induction of Micromolar Levels of nicotinamide and Tryptophan in the Urine. (Pero, Lund: Phytotherapy Res. 2010) View Study

  22. Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. (Guthrie, Gearhart, Fulton and Fechter: Brain Research 2011) View Study

  23. Dynamic Compartmentalization of DNA Repair Proteins Within Spiral Ganglion Neurons in Response to Noise Stress Guthrie, International Journal of Neuroscience, 2012) View Study

  24. Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is associated with Otoprotection from Noise Injury. (Guthrie and Xu, Otolaryngology, 2013) View Study

  25. Preservation of Neural Sensitivity After Noise-Induced Suppression of Sensory Function (Guthrie, Journal of the American Academy of Audiology, 2016) View Study

  26. Noise Induced Hearing Loss (Guthrie, Xu) View Study

  27. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. (Shi, Lu, Zhao, Wang, Wilson, Guan, Duan, Chang and Zhao: Neurochemistry International 2013) View Study

  28. AC-11 claims substantiation document. (Zwiren 2010) View Document

  29. Protectagen® (with AC-11®) Powerful Botanical Support for Inflammation, DNA Repair, Immune Function and Gastrointestinal Healing. (Product Monograph, Prothera Inc, 2010) View Study

  30. CYP450 Study View Study