Patent No. 6,964,784

"Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, and anti-tumor and DNA repair processes of warm blooded animals."

Patent Number 6,964,784: This patent provides protection for the administration and pharmaceutical use of an isolated purified active ingredient of the Uncaria composition called Carboxy Alkyl Esters and quinic acid alkyl Esters directed towards enhancing the immune system, decreasing inflammation and up regulating DNA Repair processes in mammals.

Patent No. 7,579,023

"Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."

Patent Number 7,579,023: This patent identifies an isolated bioactive component in the Uncaria composition as a quinic acid analog specifically, a quinic acid lactone in a pharmaceutical composition. This further identifies the active ingredients responsible for DNA Repair, immune enhancement and anti-Inflammatory properties of ac-11.

Patent No. 7,595,064

"Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."

Patent Number 7,595,064: This patent is directed to a method of preparing and administering quinic acid or a quinic acid salt to enhance DNA Repair further identifying the active ingredients in ac-11® and application to DNA Repair.

Patent No. 7,955,626

"Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester."

Patent Number 7,955,626: This patent covers the administration and pharmaceutical use of an isolated purified quinic acid alkyl ester or carboxy alkyl ester for DNA Repair or treating disorders associated with deficient DNA Repair processes.

Patent No. 7,947,312

"Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals."

Patent Number 7,947,312: This patent covers a method of enhancing DNA Repair or treating disorders associated therewith by administering quinic acid or quinic acid salt or a chelate thereof and further broadening the coverage of the actives of ac-11 and its therapeutic claims.

Patent No. 8,372,448

“Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester.”

Patent Number 8,372,448: This patent is directed toward a method for enhancing the response to tumor formation or growth in a mammal by inhibiting TNF-Alpha production or inducing apoptosis of white blood cells by administering a pharmaceutically effective amount of purified, isolated quinic alkyl esters having an UV absorption of approximately 200 nanometers and a bioassay efficacy using IC50 in HL60 cell line of less than 100 micrograms per milliliter, where said amount is effective to inhibit TNF-Alpha production or to induce apoptosis of white blood cells where administration is other than topical.

Patent No. 8,372,449

“Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester.”  

Patent Number: 8,372,449: This patent is directed toward a method of enhancing the response to tumor formation and growth in a mammal by administering a pharmaceutical composition comprising a purified isolated compound selected from a group consisting of quinic acid and quinic acid salt, where said quinic acid and quinic acid salt may form an ammonium salt or chelate in an amount to inhibit TNF-alpha production to induce apoptosis of white blood cells having a bioassay efficacy using IC50 in HL-60 cell line of approximately 500 micrograms per milliliter or less where application is other than topical.

Patent No. 10,098,922

“Increasing Telomere Length in a Cell”

Patent No. 10,098,922: This patent is directed toward administering a pharmaceutically effective amount of an aqueous extract of an Uncaria species for a period of time sufficient to increase the length of telomeres in a cell.

Patent No. US 11,883,457 Bl

Title: Method of Enhancing Cognition in Individuals with Healthy Brain Function.

Filed: September 6, 2022

Patent No. 9,457,009

Patent No. 9,457,009: “Methods and Compositions for Preventing and Treating Auditory Dysfunctions” This invention is directed towards methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically effective salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.

Inventor:* Guthrie, O’Neil W.
Assignee: The United States of America As represented by the Department of Veterans Affairs.

Patent No. 9,889,107

Patent No. 9,889,107: “Methods and Compositions for Preventing and Treating Auditory Dysfunctions” This invention is a divisional of patent number 9,457,009 and is directed towards methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically effective salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.

Inventor: Guthrie, O’Neil W.
Assignee: The United States of America As represented by the Department of Veterans Affairs.